Chicago Cubs baseball all-time roster of players with the last name starting with the letter “O.”
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| Mike O’Berry | C | 1980 |
| John O’Brien | 2B | 1893 |
| Pete O’Brien | 2B | 1890 |
| Johnny O’Connor | C | 1916 |
| Ken O’Dea | C | 1935-1938 |
| Bob O’Farrell | C | 1915-1925, 1934 |
| Hal O’Hagan | 1B | 1902 |
| Troy O’Leary | LF | 2003 |
| Ryan O’Malley | P | 2006-2007 |
| Emmett O’Neill | P | 1946 |
| Jack O’Neill | C | 1904-1905 |
| Will Ohman | P | 2000-2001, 2005-2007 |
| Augie Ojeda | 2B | 2000-2003, 2006, 2011 |
| Gene Oliver | C | 1968-1969 |
| Nate Oliver | 2B | 1969 |
| Barney Olsen | OF | 1941 |
| Vern Olsen | P | 1939-1946 |
| Mike Olt | 3B | 2013-2015 |
| Steve Ontiveros | 3B | 1977-1980 |
| Rey Ordonez | SS | 2004 |
| Kevin Orie | 3B | 1997-1998, 2002 |
| Jose Ortiz | OF | 1971 |
| Ramon Ortiz | P | 2011 |
| Bob Osborn | P | 1925-1930 |
| Donovan Osborne | P | 2002 |
| Tiny Osborne | P | 1922-1924 |
| Johnny Ostrowski | 3B | 1943-1946 |
| Reggie Otero | 1B | 1945 |
| Billy Ott | OF | 1962-1964 |
| Dave Otto | P | 1994 |
| Orval Overall | P | 1906-1913 |
| Ernie Ovitz | P | 1911 |
| Dave Owen | SS | 1983-1985 |
| Mickey Owen | C | 1949-1951 |