Chicago Cubs baseball all-time roster of players with the last name starting with the letter “E.”
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| Don Eaddy | 3B | 1959 |
| Bill Eagan | 2B | 1893 |
| Howard Earl | OF | 1890 |
| Arnold Earley | P | 1966 |
| Mal Eason | P | 1900-1902 |
| Roy Easterwood | C | 1944 |
| Rawly Eastwick | P | 1981 |
| Vallie Eaves | P | 1941-1942 |
| Angel Echevarria | 1B | 2002 |
| Dennis Eckersley | P | 1984-1986 |
| Charlie Eden | OF | 1877 |
| Tom Edens | P | 1995 |
| Jim Edmonds | CF | 2008 |
| Carl Edwards Jr. | P | 2013-2019 |
| Bruce Edwards | C | 1951-1954 |
| Hank Edwards | OF | 1949-1950 |
| Dave Eggler | OF | 1877 |
| Ed Eiteljorge | P | 1890 |
| Lee Elia | SS | 1968 |
| Pete Elko | 3B | 1943-1944 |
| Allen Elliott | 1B | 1923-1924 |
| Carter Elliott | SS | 1921 |
| Rowdy Elliott | C | 1916-1918 |
| Jim Ellis | P | 1967 |
| Dick Ellsworth | P | 1958-1966 |
| Don Elston | P | 1953, 1957-1964 |
| Mario Encarnacion | LF | 2002 |
| Steve Engel | P | 1985 |
| Woody English | SS | 1927-1936 |
| Al Epperly | P | 1938 |
| Paul Erickson | P | 1941-1948 |
| Frank Ernaga | OF | 1957-1958 |
| Dick Errickson | P | 1942 |
| Shawn Estes | P | 2003 |
| Chuck Estrada | P | 1966 |
| Uel Eubanks | P | 1922 |
| Bill Everitt | 3B | 1895-1900 |
| Johnny Evers | 2B | 1902-1913 |
| Scott Eyre | P | 2006-2008 |