Chicago Cubs baseball all-time roster of players with the last name starting with the letter “U.”
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| Koji Uehara | P | 2016-2017 |
| Duane Underwood Jr. | P | 2012, 2016-2019 (Present) |
| John Upham | P | 1967-1968 |
| Bob Usher | PH | 1952 |